Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.69 |
| ▸ | CDK1 | P06493 | 10/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 8/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 8/20 | 0.60 |
| ▸ | CDK2 | P24941 | 4/20 | 0.60 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.60 |
| ▸ | CDK4 | P11802 | 2/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.60 |
| ▸ | CCND1 | P24385 | 2/20 | 0.60 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.60 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.60 |
| ▸ | CLK1 | P49759 | 2/20 | 0.60 |
| ▸ | CLK3 | P49761 | 2/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24339601 | 0.81 | JAK2 (1.00) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5726338 | 0.80 | CDK1 (0.73) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL21067547 | 0.78 | CCNB2 (0.67) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5964775 | 0.76 | CCNB2 (0.64) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| Jnj-7706621 SCHEMBL1060773 | 0.75 | CDK1 (1.00) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL28198387 | 0.73 | CCNB2 (0.61) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5964695 | 0.73 | CCNB2 (1.00) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL1394721 | 0.72 | CCNB2 (1.00) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5725974 | 0.72 | CDK1 (0.78) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5726628 | 0.72 | JAK2 (0.70) | JAK2CDK1CCNB2CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888380-B2 | 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-02-15 | — | — | US | disclosed |