Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 1.00 |
| ▸ | CDK1 | P06493 | 10/20 | 0.63 |
| ▸ | CCNB2 | O95067 | 9/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.63 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.63 |
| ▸ | AURKA | O14965 | 3/20 | 0.63 |
| ▸ | CDK2 | P24941 | 3/20 | 0.63 |
| ▸ | CDK4 | P11802 | 2/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.63 |
| ▸ | CCND1 | P24385 | 2/20 | 0.63 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.63 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.63 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.63 |
| ▸ | CLK1 | P49759 | 2/20 | 0.63 |
| ▸ | CLK3 | P49761 | 2/20 | 0.63 |
| ▸ | GSK3A | P49840 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726338 | 0.82 | CDK1 (0.73) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL12893409 | 0.81 | JAK2 (0.69) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL21067547 | 0.80 | CCNB2 (0.67) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5964775 | 0.78 | CCNB2 (0.64) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| Jnj-7706621 SCHEMBL1060773 | 0.77 | CDK1 (1.00) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL28198387 | 0.76 | CCNB2 (0.61) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5964695 | 0.76 | CCNB2 (1.00) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL1394721 | 0.75 | CCNB2 (1.00) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5725974 | 0.74 | CDK1 (0.78) | JAK2CDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5726628 | 0.74 | JAK2 (0.70) | JAK2CDK1CCNB2CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220112166-A1 | Selective JAK2 Pseudokinase Ligands and Methods of Use | YALE UNIVERSITY | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112166-A1 | Selective JAK2 Pseudokinase Ligands and Methods of Use | JAK2, JAK1, MCL1 | JAK2 1/4885CDK1 316/4885CCNB2 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.