Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | FAAH | O00519 | 3/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 11/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13600348 | 0.83 | GPR183 (0.53) | KDRFAAHTBK1 | |
| SCHEMBL13003255 | 0.81 | ACKR3 (0.46) | KDR | |
| SCHEMBL13319465 | 0.81 | ACKR3 (0.46) | KDRTBK1 | |
| SCHEMBL12409942 | 0.78 | KDR (0.42) | KDRTBK1 | |
| SCHEMBL13003995 | 0.78 | KDR (0.36) | KDR | |
| SCHEMBL12409965 | 0.76 | KDR (0.36) | KDRTBK1 | |
| SCHEMBL13003253 | 0.71 | GSK3B (0.45) | TBK1 | |
| SCHEMBL13003443 | 0.71 | RECQL (0.46) | — | |
| SCHEMBL14007697 | 0.71 | PKM (0.46) | — | |
| SCHEMBL13003276 | 0.70 | ACKR3 (0.44) | TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879880-B2 | such as [4-[(2-aminopyridin-4-yl)methyl]piperazin-1-yl]-[4-(pyridin-4-ylamino)phenyl]methanone, used for the treatment of inflammatory diseases, allergic conditions, diabetes, obesity, metabolic syndrome, cognition disorder, cardiovascular and nervous system disorders | SCHERING CORPORATION (US) | 2011-02-01 | — | — | US | disclosed |
| US-20070142394-A1 | Substituted aniline derivatives useful as histamine H3 antagonists | SCHERING CORPORATION | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142394-A1 | Substituted aniline derivatives useful as histamine H3 antagonists | HRH3, CHRM2, HCRTR2 | KDR 3611/4885FAAH 283/4885TBK1 4533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.