Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.61 |
| ▸ | CA4 | P22748 | 2/20 | 0.61 |
| ▸ | CA1 | P00915 | 7/20 | 0.39 |
| ▸ | CES1 | P23141 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28222795 | 0.84 | CA4 (0.85) | CA2CA4HDAC3HDAC4HDAC1 | |
| Citric Acid SCHEMBL28119995 | 0.84 | CA4 (0.63) | CA2CA4CA1CES1HDAC3 | |
| Citric Acid SCHEMBL28003552 | 0.83 | CA4 (0.53) | CA2CA4CES1MAPTMAPK1 | |
| Citric Acid SCHEMBL10632799 | 0.83 | CA4 (0.53) | CA2CA4CES1HDAC3HDAC4 | |
| Citric Acid SCHEMBL11207540 | 0.81 | CA4 (0.59) | CA2CA4CES1HDAC3HDAC4 | |
| Citric Acid SCHEMBL29103874 | 0.80 | CA4 (0.94) | CA2CA4HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL6238058 | 0.80 | CA4 (0.63) | CA2CA4CA1HDAC3HDAC4 | |
| Citric Acid SCHEMBL6238060 | 0.80 | CA4 (0.63) | CA2CA4CA1HDAC3HDAC4 | |
| Citric Acid SCHEMBL104570 | 0.79 | CA4 (0.55) | CA2CA4CES1HDAC3HDAC4 | |
| Citric Acid SCHEMBL106887 | 0.79 | CA4 (0.55) | CA2CA4CES1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230014574-A1 | Bioactive Dairy Products and Processes for Their Manufacture | BHANDARI, VIVEK, MR. (NZ) | 2023-01-19 | — | — | US | disclosed |
| US-20200260752-A1 | Bioactive Dairy Products and Processes for Their Manufacture | INNOVATIVE DAIRY CONSULTANTS LIMITED (NZ) | 2020-08-20 | — | — | US | disclosed |
| US-8911712-B2 | Multi-purposed dentifrice | CHURCH & DWIGHT, CO., INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-20130189201-A1 | MULTI-PURPOSED DENTIFRICE | CHURCH & DWIGHT CO., INC. (US) | 2013-07-25 | — | — | US | disclosed |
| WO-2012047781-A1 | MULTI-PURPOSED DENTIFRICE | CHURCH & DWIGHT CO., INC. (US) | 2012-04-12 | — | — | WO | disclosed |
| EP-0845976-B1 | REMINERALIZING PRODUCTS AND METHODS FOR TEETH | CHURCH & DWIGHT CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0850042-A4 | COMPOSITION AND METHOD FOR REMINERALIZATION OF TEETH | ENAMELON INC (US) | 2000-01-05 | — | — | EP | disclosed |
| EP-0845976-A4 | REMINERALIZING PRODUCTS AND METHODS FOR TEETH | ENAMELON INC (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5958380-A | MIXTURE OF CATIONIC AND ANIONIC WATER SOLUBLE COMPOUNDS AND STABILIZER | ENAMELON, INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5866102-A | CONTAINING CALCIUM AND PHOSPHATE COMPOUNDS | ENAMELON, INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0850042-A1 | COMPOSITION AND METHOD FOR REMINERALIZATION OF TEETH | Enamelon, Inc. (US) | 1998-07-01 | — | — | EP | disclosed |
| EP-0845976-A1 | REMINERALIZING PRODUCTS AND METHODS FOR TEETH | Enamelon, Inc. (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5645853-A | CALCIUM PHOSPHATE | ENAMELON INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5614175-A | CALCIUM AND PHOSPHATE SALTS | ENAMELON INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1997006774-A1 | REMINERALIZING PRODUCTS AND METHODS FOR TEETH | ENAMELON, INC. (US) | 1997-02-27 | — | — | WO | disclosed |
| WO-1997005854-A1 | COMPOSITION AND METHOD FOR REMINERALIZATION OF TEETH | ENAMELON, INC. (US) | 1997-02-20 | — | — | WO | disclosed |
| US-5571502-A | WATER SOLUBILITY CALCIUM SALT, PHOSPHATE SALTS WITH NONAQUEOUS VEHICLES | ENAMELON RESEARCH (US) | 1996-11-05 | — | — | US | disclosed |