Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6238058 | 1.00 | CA4 (0.63) | CA4ALOX15CYP3A4CASP1CASP7 | |
| Citric Acid SCHEMBL29054134 | 0.96 | CA4 (0.57) | CA4ALOX15CYP3A4CASP1CASP7 | |
| Citric Acid SCHEMBL6238056 | 0.87 | CA4 (0.45) | CA4ALOX15CYP3A4CASP1CASP7 | |
| Citric Acid SCHEMBL28222795 | 0.82 | CA4 (0.85) | CA4CASP1HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL28119995 | 0.81 | CA4 (0.63) | CA4GAAMAPTHDAC3HDAC1 | |
| Citric Acid SCHEMBL1289441 | 0.80 | CA2 (0.61) | CA4ALOX15CYP3A4SMN1; SMN2MAPT | |
| Citric Acid SCHEMBL3657 | 0.79 | CA4 (1.00) | CA4CASP1HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL14675762 | 0.79 | CA4 (0.89) | CA4CASP1ALDH1A1 | |
| Citric Acid SCHEMBL11060179 | 0.79 | CA4 (1.00) | CA4CASP1HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL715802 | 0.79 | CA4 (1.00) | CA4CASP1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119346-B1 | RNA CANCER VACCINE AND METHODS FOR ITS USE | WAYNE JOHN CANCER INST (US) | 2005-06-01 | — | — | EP | disclosed |
| US-6472375-B1 | DNA vaccine and methods for its use | JOHN WAYNE CANCER INSTITUTE | 2002-10-29 | — | — | US | disclosed |
| US-6432925-B1 | TUMOR ANTIGEN | JOHN WAYNE CANCER INSTITUTE | 2002-08-13 | — | — | US | disclosed |
| EP-1119346-A2 | RNA CANCER VACCINE AND METHODS FOR ITS USE | John Wayne Cancer Institute (US) | 2001-08-01 | — | — | EP | disclosed |
| EP-1108028-A2 | DNA CANCER VACCINE AND METHODS FOR ITS USE | John Wayne Cancer Institute (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012127-A2 | DNA CANCER VACCINE AND METHODS FOR ITS USE | JOHN WAYNE CANCER INSTITUTE (US) | 2000-03-09 | — | — | WO | disclosed |
| WO-1999052503-A2 | RNA CANCER VACCINE AND METHODS FOR ITS USE | JOHN WAYNE CANCER INSTITUTE (US) | 1999-10-21 | — | — | WO | disclosed |