Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ILK | Q13418 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742663 | 0.85 | CSNK2A2 (0.40) | CSNK2A2CSNK2BCSNK2A1KDRPAK4 | |
| SCHEMBL14163466 | 0.84 | CSNK2A2 (0.60) | CSNK2A2CSNK2BCSNK2A1KDRPAK4 | |
| SCHEMBL13686291 | 0.84 | CSNK2A2 (0.39) | CSNK2A2CSNK2BCSNK2A1KDRPAK4 | |
| SCHEMBL3955904 | 0.84 | KDM4E (0.43) | CSNK2A2CSNK2BCSNK2A1KDRALDH1A1 | |
| SCHEMBL3835960 | 0.83 | MAP3K8 (0.39) | CSNK2A2CSNK2BCSNK2A1KDRNPC1 | |
| SCHEMBL763925 | 0.79 | TSHR (0.43) | NPC1ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL3881086 | 0.77 | CSNK2A2 (0.48) | CSNK2A2CSNK2BCSNK2A1KDRPAK4 | |
| SCHEMBL29964839 | 0.72 | CSNK2A2 (0.52) | CSNK2A2CSNK2BCSNK2A1KDRPAK4 | |
| SCHEMBL27138637 | 0.72 | CSNK2A1 (1.00) | CSNK2A2CSNK2BCSNK2A1KDRPAK4 | |
| SCHEMBL3816187 | 0.71 | MAPK1 (0.41) | CSNK2A2CSNK2BCSNK2A1KDRPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904503-B1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-11-06 | — | — | EP | disclosed |
| US-7884123-B2 | 3-(1H-indol-2-yl)-1H-thieno[2,3-c]pyrazole-5-(N-phenoxycarboxamide); anticancer agents; protein kinase inhibitors | AVENTIS PHARMA S.A. (FR) | 2011-02-08 | — | — | US | disclosed |
| US-7595320-B2 | Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, process for preparing them, compositions containing them and use thereof | AVENTIS PHARMA S.A. (FR) | 2009-09-29 | — | — | US | disclosed |
| US-20080146542-A1 | Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, Process for Preparing Them, Compositions Containing Them and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-06-19 | — | — | US | disclosed |
| US-20080058402-A1 | Substituted Thieno[2,3-c]pyrazoles, Process for Preparing Them, Compositions Containing Them, and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146542-A1 | Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, Process for Preparing Them, Compositions Containing Them and Use Thereof | TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CASP3 | CSNK2A2 885/4885CSNK2B 821/4885CSNK2A1 891/4885 |
| US-20080058402-A1 | Substituted Thieno[2,3-c]pyrazoles, Process for Preparing Them, Compositions Containing Them, and Use Thereof | TYMS, TYMP, CYP3A43 | CSNK2A2 730/4885CSNK2B 778/4885CSNK2A1 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.