Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 2/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12896017 | 0.84 | HDAC3 (0.37) | P2RX3HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL12896021 | 0.83 | HDAC3 (0.38) | P2RX3HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL8238631 | 0.80 | HDAC6 (0.57) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12295630 | 0.79 | HDAC3 (0.67) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15341327 | 0.76 | ALDH1A1 (0.42) | P2RX3HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL13304527 | 0.75 | HDAC6 (0.43) | P2RX3HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL12295649 | 0.75 | HDAC3 (0.66) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13535015 | 0.75 | KDM4E (0.42) | P2RX3HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL12295657 | 0.75 | HDAC3 (0.67) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10175644 | 0.75 | BCHE (0.47) | P2RX3HDAC6HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888360-B2 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-02-15 | — | — | US | disclosed |
| US-7888360-B2 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-02-15 | — | — | US | disclosed |
| US-20090036463-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-02-05 | — | — | US | disclosed |
| US-20090036463-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036463-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | P2RX3 1258/4885HDAC6 13/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.