Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13038662 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL12884095 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL14393674 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL13038043 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL1219529 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL1220239 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL1219526 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL1221071 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL12884069 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 | |
| SCHEMBL8248886 | 1.00 | GPR119 (0.47) | GPR119KDM4EPKMNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039838-A1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039838-A1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | ERBB2, ERBB4, ERBB3 | GPR119 2060/4885KDM4E 2206/4885PKM 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.