Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 6/20 | 0.57 |
| ▸ | CDK9 | P50750 | 6/20 | 0.57 |
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12896769 | 0.86 | MEN1 (0.50) | CCNT1CDK9OPRM1OPRK1OPRL1 | |
| SCHEMBL12897167 | 0.85 | DRD2 (0.61) | OPRM1DRD2GRM2HTR7MEN1 | |
| SCHEMBL18361621 | 0.83 | SLC6A2 (0.51) | CDK9SLC6A3CHRM4CHRM1HTR2A | |
| SCHEMBL12897021 | 0.81 | CHRM4 (0.56) | CCNT1CDK9DRD2SLC6A3CHRM4 | |
| SCHEMBL12896523 | 0.79 | CHRM4 (0.63) | CCR5CHRM4CHRM1HTR7CHRM2 | |
| SCHEMBL12897186 | 0.78 | CCNT1 (0.48) | CCNT1CDK9CCR5OPRM1OPRK1 | |
| SCHEMBL12897596 | 0.78 | DRD2 (0.59) | OPRM1DRD2GRM2HTR7MEN1 | |
| SCHEMBL12897160 | 0.77 | CCNT1 (0.47) | CCNT1CDK9CCR5OPRM1OPRK1 | |
| SCHEMBL12896860 | 0.77 | CCNT1 (0.47) | CCNT1CDK9CCR5OPRM1OPRK1 | |
| SCHEMBL12896714 | 0.77 | HTR2A (0.43) | CCR5DRD2SLC6A3GRM2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7880007-B2 | such as 1-bicyclo[2.2.1]hept-2-yl-4-(4-methoxy-2-methyl-phenyl)-piperidine, used for the treatment of chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |
| US-7880007-B2 | such as 1-bicyclo[2.2.1]hept-2-yl-4-(4-methoxy-2-methyl-phenyl)-piperidine, used for the treatment of chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |