Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1266524 | 0.85 | PTGDR2 (0.49) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL12896972 | 0.85 | PTGDR2 (0.49) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL12897608 | 0.82 | DRD2 (0.46) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL12897236 | 0.82 | F10 (0.46) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL1267220 | 0.81 | DRD2 (0.48) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL12896751 | 0.81 | CHRM4 (0.45) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL12896481 | 0.80 | MEN1 (0.45) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL12897362 | 0.79 | DRD2 (0.47) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL12896796 | 0.78 | DRD2 (0.44) | DRD2ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL1267329 | 0.78 | DRD2 (0.43) | DRD2ADRA1DADRA1AADRA1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7880007-B2 | such as 1-bicyclo[2.2.1]hept-2-yl-4-(4-methoxy-2-methyl-phenyl)-piperidine, used for the treatment of chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |
| US-7880007-B2 | such as 1-bicyclo[2.2.1]hept-2-yl-4-(4-methoxy-2-methyl-phenyl)-piperidine, used for the treatment of chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |