Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levomilnacipran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 10/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | HTR2C | P28335 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milnacipran SCHEMBL1156056 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL16163256 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| 1R,2S-Milnacipran SCHEMBL4434769 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL1148742 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| 1R,2S-Milnacipran SCHEMBL161558 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| 1R,2S-Milnacipran SCHEMBL8099 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL12027608 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| 1R,2S-Milnacipran SCHEMBL30083111 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Milnacipran SCHEMBL114034 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL1707471 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046247-A2 | PROCESS FOR THE PREPARATION OF (±M1R(S), 2SRR)L-2-(AMINOMETHYL)-N,N-DIETHYL-L-PHENYLCYCLOPROPANE CARBOXAMIDE HYDROCHLORIDE | MSN LABORATORIES LIMITED (IN) | 2012-04-12 | — | — | WO | disclosed |