Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1R,2S-Milnacipran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 10/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | HTR2C | P28335 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milnacipran SCHEMBL1156056 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL16163256 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| 1R,2S-Milnacipran SCHEMBL4434769 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL1289763 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL1148742 | 1.00 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| 1R,2S-Milnacipran SCHEMBL8099 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL12027608 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| 1R,2S-Milnacipran SCHEMBL30083111 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Milnacipran SCHEMBL114034 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 | |
| Levomilnacipran SCHEMBL1707471 | 0.99 | SLC6A2 (1.00) | SLC6A2KDM4EMAPK1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2145 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121618975-B | Time residual processing circuit, correlated multi-sampling method, SS-ADC circuit and chip | ANHUI UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-119592824-A | Production process of Keel bar material | 南京达迈科技实业股份有限公司 | 2025-03-11 | — | — | CN | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| US-20240307386-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. | 2024-09-19 | — | — | US | claimed |
| US-20240280514-A1 | X-RAY BAGGAGE AND PARCEL INSPECTION SYSTEM WITH EFFICIENT THIRD-PARTY IMAGE PROCESSING | BATTELLE MEMORIAL INSTITUTE | 2024-08-22 | — | — | US | claimed |
| CN-118050434-A | Method for detecting related substances in milnacipran hydrochloride intermediate compound of formula III | 四川科瑞德制药股份有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-118050435-A | Method for efficiently separating and detecting related substances in milnacipran hydrochloride | 四川科瑞德制药股份有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-117825531-A | Gas chromatography of milnacipran hydrochloride and related substances in preparation thereof | 四川科瑞德制药股份有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-117783306-A | Gas chromatography method for milnacipran hydrochloride and mutagenic impurities in milnacipran hydrochloride preparation | 四川科瑞德制药股份有限公司 | 2024-03-29 | — | — | CN | claimed |
| CN-117765193-A | Rapid surface reconstruction method for remote sensing scene | 哈尔滨工程大学 | 2024-03-26 | — | — | CN | claimed |
| EP-1094791-B1 | THIXOTROPIC FORMULATIONS FOR FILLING CAPSULES | PF MEDICAMENT (FR) | 2003-04-16 | — | — | EP | claimed |
| WO-2003029766-A2 | APPARATUS AND METHOD FOR MEASURING COLOUR | DIGIEYE PLC (GB) | 2003-04-10 | — | — | WO | claimed |
| EP-0807024-B2 | COATING METHODS AND COMPOSITIONS FOR PRODUCTION OF DIGITIZED STEREOSCOPIC POLARIZING IMAGES | ROWLAND INST FOR SCIENCE (US) | 2002-11-27 | — | — | EP | claimed |
| WO-2002054169-A2 | A DATA INPUT DEVICE | VKB INC. (US) | 2002-07-11 | — | — | WO | claimed |
| CN-1308522-A | Thixotropic formulations for filling hard capsules | PF MEDICAMENT (FR) | 2001-08-15 | — | — | CN | claimed |
| US-6026199-A | Method and apparatus for halftoning grey value signals | Oce--Technologies B.V. (NL) | 2000-02-15 | — | — | US | claimed |
| EP-0426712-A1 | FILM NOISE REDUCTION BY APPLICATION OF BAYES THEOREM TO POSITIVE/NEGATIVE FILM | EASTMAN KODAK COMPANY (US) | 1991-05-15 | — | — | EP | claimed |
| WO-1990001240-A1 | FILM NOISE REDUCTION BY APPLICATION OF BAYES THEOREM TO POSITIVE/NEGATIVE FILM | EASTMAN KODAK COMPANY (US) | 1990-02-08 | — | — | WO | claimed |
| EP-0294456-A1 | TRANSVERSE PRINTING CONTROL SYSTEM FOR MULTIPLE PRINT/CARTRIDGE PRINTER. | EASTMAN KODAK CO (US) | 1988-12-14 | — | — | EP | claimed |
| WO-1988004612-A1 | TRANSVERSE PRINTING CONTROL SYSTEM FOR MULTIPLE PRINT/CARTRIDGE PRINTER | EASTMAN KODAK COMPANY (US) | 1988-06-30 | — | — | WO | claimed |