Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12899439 | 1.00 | OPRM1 (0.37) | OPRM1OPRL1OPRK1SIGMAR1TNKS | |
| SCHEMBL12899395 | 0.88 | OPRM1 (0.38) | OPRM1OPRL1OPRK1SIGMAR1 | |
| SCHEMBL5578842 | 0.85 | OPRM1 (0.45) | OPRM1OPRL1OPRK1SIGMAR1TNKS | |
| SCHEMBL12084297 | 0.82 | OPRM1 (0.53) | OPRM1OPRL1OPRK1SIGMAR1GRIN2D | |
| SCHEMBL13004093 | 0.82 | OPRM1 (0.38) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL12084888 | 0.82 | OPRM1 (0.38) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL15339857 | 0.82 | OPRM1 (0.38) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL12084920 | 0.82 | OPRM1 (0.38) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL12084762 | 0.82 | OPRM1 (0.38) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL12084665 | 0.82 | OPRM1 (0.38) | OPRM1OPRL1OPRK1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879834-B2 | spiro[indoline-3,4'-piperidine] derivatives, used for the treatment of nervous system disorders, chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects, Alzheimer's disiease, obesity or as analgesics and antidepressants | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |