Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12899988 | 0.86 | DPP4 (0.53) | DPP4HRH2CHRM2HTR1AADRA2A | |
| SCHEMBL12899992 | 0.86 | DPP4 (0.55) | DPP4HRH2CHRM2HTR1AADRA2A | |
| SCHEMBL8006660 | 0.86 | HTR2A (0.62) | DPP4HRH2CHRM2HTR1AADRA2A | |
| SCHEMBL2004500 | 0.86 | HTR2A (0.62) | DPP4HRH2CHRM2HTR1AADRA2A | |
| SCHEMBL12503482 | 0.73 | KDM4E (0.48) | DPP4HRH2CHRM2HTR1AADRA2A | |
| SCHEMBL12568773 | 0.72 | HTR2A (0.70) | DPP4HRH2CHRM2HTR1AADRA2A | |
| SCHEMBL12413282 | 0.72 | HTR2A (0.70) | DPP4HRH2CHRM2HTR1AADRA2A | |
| SCHEMBL19256735 | 0.72 | HTR2A (0.58) | DPP4HRH2CHRM2HTR1AADRA2A | |
| SCHEMBL19256257 | 0.70 | HTR2A (0.62) | HRH2CHRM2HTR1AADRA2ADRD2 | |
| SCHEMBL11575385 | 0.70 | ALDH1A1 (0.47) | HRH1KMT2APOLBMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012654-A1 | HYDROXYASENAPINE COMPOUNDS, DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |