Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CCR6 | P51684 | 4/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.33 |
| ▸ | CCR7 | P32248 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1268612 | 0.99 | PIK3C3 (0.35) | CCKBRPIK3C3PPARGPTGDRPTGDR2 | |
| SCHEMBL1269591 | 0.93 | PIK3C3 (0.34) | CCKBRPIK3C3PPARGPTGDRPTGDR2 | |
| SCHEMBL1269589 | 0.90 | PTGDR2 (0.40) | PPARGPTGDRPTGDR2ALDH1A1 | |
| SCHEMBL1269823 | 0.88 | CCKBR (0.41) | CCKBRPIK3C3PPARGGAAHCRTR1 | |
| SCHEMBL1268781 | 0.88 | CCKBR (0.38) | CCKBRPIK3C3PPARGPTGDRPTGDR2 | |
| SCHEMBL1269298 | 0.87 | CCKBR (0.40) | CCKBRPIK3C3PPARGGAAHCRTR1 | |
| SCHEMBL1269048 | 0.87 | PIK3C3 (0.39) | CCKBRPIK3C3PPARGPTGDRPTGDR2 | |
| SCHEMBL1269608 | 0.85 | HTT (0.38) | PIK3C3PPARGPTGDRPTGDR2GAA | |
| SCHEMBL1269094 | 0.85 | PIK3C3 (0.38) | CCKBRPIK3C3PPARGPTGDRPTGDR2 | |
| SCHEMBL1269095 | 0.85 | PIK3C3 (0.37) | CCKBRPIK3C3PPARGPTGDRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893077-B2 | Bisaryl-sulfonamides | AMGEN INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090221584-A1 | Bisaryl-sulfonamides | AMGEN INC. | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221584-A1 | Bisaryl-sulfonamides | PPARD, PPARA, PPARG | CCKBR 1384/4885PIK3C3 1316/4885PPARG 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.