Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.32 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15690188 | 0.82 | PDE10A (0.35) | PDE10ADYRK1ASCN5A | |
| SCHEMBL15690266 | 0.82 | PDE10A (0.35) | PDE10ADYRK1AKCNN3 | |
| SCHEMBL30852894 | 0.77 | KCNN3 (0.39) | PDE10AKCNN3KDM4E | |
| SCHEMBL2968326 | 0.77 | AKT1 (0.39) | DYRK1AKDM4E | |
| SCHEMBL22978874 | 0.76 | PDE10A (0.32) | PDE10ADYRK1AKCNN3KCNN1KCNN2 | |
| SCHEMBL22996432 | 0.74 | SIRT2 (0.31) | PDE10A | |
| SCHEMBL2978671 | 0.71 | KDR (0.40) | — | |
| SCHEMBL22996562 | 0.71 | KMT2A (0.35) | — | |
| SCHEMBL31514478 | 0.70 | MAPK14 (0.41) | KCNN3KCNN1KCNN2TDP1P2RX7 | |
| SCHEMBL405358 | 0.70 | DYRK1A (0.47) | PDE10ADYRK1AKCNN3SCN5AKCNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047569-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |