Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13319926 | 0.87 | DAO (0.56) | DAOPOLBGAAALOX15KDM4E | |
| SCHEMBL1170958 | 0.87 | DAO (0.56) | DAOPOLBGAAITGB3ITGA2B | |
| SCHEMBL12904064 | 0.82 | DAO (0.58) | DAOPOLBGAAALOX15KDM4E | |
| SCHEMBL13319927 | 0.81 | DAO (0.56) | DAOPOLBGAAALOX15KDM4E | |
| SCHEMBL12904066 | 0.80 | DAO (0.67) | DAOPOLBGAAALOX15KDM4E | |
| SCHEMBL2406834 | 0.78 | DAO (0.65) | DAOPOLBGAAALOX15 | |
| SCHEMBL679809 | 0.77 | DAO (1.00) | DAOPOLBGAAALOX15KDM4E | |
| SCHEMBL17883341 | 0.77 | DAO (0.62) | DAOPOLBGAA | |
| SCHEMBL1171650 | 0.76 | DAO (0.96) | DAOPOLBGAAALOX15KDM4E | |
| SCHEMBL12880134 | 0.75 | DAO (0.59) | DAOPOLBGAAALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011017634-A2 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACORE INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2010017418-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-02-11 | — | — | WO | disclosed |