⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9587810 | 0.69 | GSK3B (0.37) | — | |
| SCHEMBL347103 | 0.65 | LDHA (0.32) | — | |
| SCHEMBL36967 | 0.65 | — | — | |
| SCHEMBL1127854 | 0.65 | — | — | |
| SCHEMBL589316 | 0.65 | — | — | |
| SCHEMBL2937688 | 0.65 | — | — | |
| SCHEMBL19900692 | 0.65 | — | — | |
| SCHEMBL75166 | 0.65 | — | — | |
| SCHEMBL996566 | 0.65 | GSK3A (0.33) | — | |
| SCHEMBL163390 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011018612-A2 | THIOL PROTECTING GROUP | UCL BUSINESS PLC (GB) | 2011-02-17 | — | — | WO | disclosed |
| US-RE40360-E1 | Methods for inhibition of angiogenesis with a composition comprising 3-hydroxythalidomide | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2008-06-03 | — | — | US | disclosed |