LDHA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL92986	0.48	11/20
SCHEMBL7624	1.00	8/20
SCHEMBL8027	1.00	7/20
SCHEMBL8347	0.66	7/20
SCHEMBL8240	0.58	7/20
SCHEMBL8014	0.55	7/20
Pki-166 (SCHEMBL173524)	0.44	7/20
Pki-166 (SCHEMBL177814)	0.44	7/20
SCHEMBL7300	1.00	6/20
SCHEMBL7814	1.00	6/20
SCHEMBL8149	0.79	6/20
SCHEMBL7988	0.70	6/20
SCHEMBL8015	0.69	6/20
SCHEMBL7731	0.67	6/20
SCHEMBL7705	0.61	6/20
SCHEMBL8154	0.56	6/20
SCHEMBL13308	1.00	5/20
SCHEMBL7923	0.84	5/20
SCHEMBL7108	0.82	5/20
SCHEMBL12031	0.80	5/20

Clinical trials — most relevant to LDHA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin Monotherapy	PHASE4	NOT_YET_RECRUITING
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients	PHASE4	NOT_YET_RECRUITING
Study to Evaluate the Safety of Pembrolizumab in Participants With Unresectable or Metastatic Melanoma or Non-small Cell Lung Cancer in India (MK-3475-593/KEYNOTE-593)	PHASE4	COMPLETED
Early Lactate-Directed Therapy in the Intensive Care Unit (ICU)	PHASE3	COMPLETED
First-line Irinotecan, Lederfolin and 5FU (FOLFIRI) and Bevacizumab in Patients With Advanced Colorectal Cancer	PHASE2	COMPLETED
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors	PHASE2	ACTIVE_NOT_RECRUITING
Study to Evaluate the Efficacy and Safety of REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)	PHASE2	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury	EARLY_PHASE1	NOT_YET_RECRUITING
Role of LDH as a Predictor of Treatment Outcomes in Hepatocellular Carcinoma	nan	UNKNOWN
Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS	nan	RECRUITING
Evaluation of Clinical Characteristics and Outcome of COVID19 Pneumonia in Assiut University Hospital	nan	UNKNOWN
Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study	nan	COMPLETED
Evaluation of Lactate Dehydrogenase as Decision Support for Admissions to Neonatal Ward	nan	COMPLETED
COVID-19 Study at the Russian Clinical and Research Center of Gerontology of the Pirogov RNRMU	nan	COMPLETED
Correlation Between Inferior Vena Cava Collapsibility Index and Serum Lactate in Poly-trauma Patients	nan	NOT_YET_RECRUITING
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Safety of D-lactate Producing Probiotics	nan	COMPLETED
Effect of PNF and Lumbar Stabilization Exercises on Muscle Strength and Endurance in Lumbar Disc Hernia	nan	COMPLETED
The Effectiveness of Surgical Treatment of Patients With Ischemic Cardiomyopathy	nan	COMPLETED
Single Effort in Air Temperature of Minus 10°C	nan	COMPLETED
13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment	nan	UNKNOWN
Study of CRP, Ferritine and D-Dimer in Covid-19 Patients Admitted To Respiratory ICU in Assuit University Hospitals	nan	UNKNOWN
Evaluation of a PCM Mattress to Treat HIE Infants During Transport	nan	UNKNOWN
Infrared Low-level Laser Therapy Before Intense Progressive Running Test of High-level Soccer Players	nan	COMPLETED
Early Lactate Clearance Rate in Sepsis	nan	UNKNOWN
Artemisinin Resistance In Malaria Treated With IV Artesunate	nan	WITHDRAWN
Effects of Protein Hydrolysate Supplementation Influencing Strength Recovery and Expression of Muscle Damage Markers Post-exercise	nan	COMPLETED
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LDHA binder may also engage these)

Protein	Name	Similarity
A0A1F3	—	1.000	A0A1F3 →
Q9BE24	—	1.000	Q9BE24 →
P19858	—	1.000	P19858 →
Q9XT87	—	1.000	Q9XT87 →
Q5R5F0	—	1.000	Q5R5F0 →
Q9PW06	—	1.000	Q9PW06 →
P04642	—	1.000	P04642 →
Q98SL0	—	1.000	Q98SL0 →
Q5R1W9	—	1.000	Q5R1W9 →
Q9PT43	—	1.000	Q9PT43 →
Q9PT42	—	1.000	Q9PT42 →
P00337	—	1.000	P00337 →
P16125	—	1.000	P16125 →
Q9YGL2	—	1.000	Q9YGL2 →
Q5E9B1	—	1.000	Q5E9B1 →
P69082	—	1.000	P69082 →
O13277	—	0.999	O13277 →
Q9PW07	—	0.999	Q9PW07 →
Q1EG91	—	0.999	Q1EG91 →
P00336	—	0.998	P00336 →
O93541	—	0.998	O93541 →
P06151	—	0.998	P06151 →
P00339	—	0.997	P00339 →
P79913	—	0.997	P79913 →
P00341	—	0.997	P00341 →
Q9W7L5	—	0.997	Q9W7L5 →
P13491	—	0.997	P13491 →
P13743	—	0.997	P13743 →
P79912	—	0.997	P79912 →
P42123	—	0.996	P42123 →