Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.57 |
| ▸ | SGK1 | O00141 | 12/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907131 | 0.88 | JAK2 (0.62) | JAK2PDPK1SGK1JAK3CDC7 | |
| SCHEMBL12907208 | 0.83 | JAK2 (0.80) | JAK2PDPK1SGK1JAK3PLK4 | |
| SCHEMBL12907224 | 0.79 | PDPK1 (0.62) | JAK2PDPK1SGK1AURKB | |
| SCHEMBL12907458 | 0.77 | JAK2 (0.67) | JAK2PDPK1JAK3CDC7PLK4 | |
| SCHEMBL6479941 | 0.77 | JAK2 (0.72) | JAK2PDPK1SGK1JAK3CDK2 | |
| SCHEMBL12907248 | 0.77 | JAK2 (0.74) | JAK2JAK3CDC7PLK4DAPK3 | |
| SCHEMBL421269 | 0.76 | JAK2 (0.77) | JAK2PDPK1SGK1JAK3CDK2 | |
| SCHEMBL3361070 | 0.75 | JAK2 (1.00) | JAK2PDPK1SGK1JAK3CDK2 | |
| SCHEMBL12907241 | 0.75 | JAK2 (1.00) | JAK2PDPK1SGK1JAK3CDK2 | |
| SCHEMBL12907464 | 0.74 | SGK1 (0.51) | JAK2PDPK1SGK1JAK3CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |