Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907444 | 0.87 | TTK (0.54) | SGK1LRRK2PDPK1TTKJAK2 | |
| SCHEMBL12907430 | 0.85 | JAK2 (0.63) | SGK1PDPK1TTKJAK2FGFR1 | |
| SCHEMBL12907131 | 0.85 | JAK2 (0.62) | SGK1DHFRPDPK1JAK2JAK3 | |
| SCHEMBL18148589 | 0.81 | JAK2 (0.51) | SGK1LRRK2DHFRPDPK1TTK | |
| SCHEMBL14397096 | 0.80 | PDPK1 (0.53) | SGK1PDPK1JAK2FGFR1FGFR2 | |
| SCHEMBL14061660 | 0.80 | LRRK2 (0.44) | SGK1LRRK2DHFRPDPK1TTK | |
| SCHEMBL12907457 | 0.79 | JAK2 (0.67) | PDPK1TTKJAK2FGFR1FGFR2 | |
| SCHEMBL12907451 | 0.78 | FGFR1 (0.70) | SGK1PDPK1JAK2FGFR1FGFR2 | |
| SCHEMBL14061443 | 0.77 | METAP2 (0.49) | LRRK2DHFRJAK2FGFR1TDO2 | |
| SCHEMBL12907471 | 0.76 | AAK1 (0.57) | PDPK1JAK2FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |