Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.59 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1254733 | 0.92 | ROCK2 (0.74) | ROCK2ROCK1AAK1 | |
| SCHEMBL3809895 | 0.85 | ROCK2 (0.59) | ROCK2ROCK1AAK1 | |
| SCHEMBL16712958 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL4662575 | 0.75 | ROCK2 (0.76) | ROCK2ROCK1 | |
| SCHEMBL12914907 | 0.74 | ROCK2 (0.61) | ROCK2ROCK1AAK1 | |
| SCHEMBL17394743 | 0.74 | ROCK2 (1.00) | ROCK2ROCK1AAK1 | |
| SCHEMBL12915605 | 0.74 | ROCK2 (0.51) | ROCK2ROCK1AAK1 | |
| SCHEMBL17394742 | 0.74 | ROCK2 (1.00) | ROCK2ROCK1AAK1 | |
| SCHEMBL23430169 | 0.73 | ROCK2 (0.59) | ROCK2ROCK1 | |
| SCHEMBL12892373 | 0.73 | ROCK2 (0.59) | ROCK2ROCK1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110038835-A1 | ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110038835-A1 | ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS | ROCK1, RHOA, ROCK2 | ROCK2 3/4885ROCK1 1/4885AAK1 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.