Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.71 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1291495 | 0.91 | GPR119 (0.71) | GPR119AKR1B1PIM1PIM2 | |
| SCHEMBL1291467 | 0.91 | GPR119 (0.71) | GPR119AKR1B1PIM1PIM2 | |
| SCHEMBL1291462 | 0.91 | GPR119 (0.71) | GPR119AKR1B1PIM1PIM2 | |
| SCHEMBL1291548 | 0.85 | GPR119 (0.84) | GPR119HPGDAKR1B1 | |
| SCHEMBL1291621 | 0.85 | GPR119 (0.84) | GPR119HPGDAKR1B1 | |
| SCHEMBL1291980 | 0.84 | GPR119 (0.72) | GPR119HPGDAKR1B1NPC1RAB9A | |
| SCHEMBL1291977 | 0.84 | GPR119 (0.72) | GPR119HPGDAKR1B1NPC1RAB9A | |
| SCHEMBL1291981 | 0.84 | GPR119 (0.72) | GPR119HPGDAKR1B1NPC1RAB9A | |
| SCHEMBL16927297 | 0.84 | GPR119 (1.00) | GPR119HPGD | |
| SCHEMBL1292036 | 0.83 | GPR119 (0.49) | GPR119SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2625177-A1 | NOVEL GPR 119 AGONISTS | Cadila Healthcare Limited (IN) | 2013-08-14 | — | — | EP | claimed |
| WO-2012046249-A1 | NOVEL GPR 119 AGONISTS | CADILA HEALTHCARE LIMITED (IN) | 2012-04-12 | — | — | WO | claimed |
| EP-2625177-A1 | NOVEL GPR 119 AGONISTS | Cadila Healthcare Limited (IN) | 2013-08-14 | — | — | EP | disclosed |
| WO-2012046249-A1 | NOVEL GPR 119 AGONISTS | CADILA HEALTHCARE LIMITED (IN) | 2012-04-12 | — | — | WO | disclosed |