Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.58 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | WNT3A | P56704 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26033240 | 0.90 | HIF1A (0.58) | HIF1AEPAS1KCNH2WNT3A | |
| SCHEMBL1018345 | 0.90 | KCNH2 (0.60) | HIF1AEPAS1KCNH2KMT2ANPC1 | |
| SCHEMBL2619556 | 0.90 | KIT (0.50) | HIF1AEPAS1 | |
| SCHEMBL2619309 | 0.88 | HIF1A (0.62) | HIF1AEPAS1KMT2ANPC1RAB9A | |
| SCHEMBL2619542 | 0.85 | HPGDS (0.50) | KCNH2WNT3AHPGDS | |
| SCHEMBL12727154 | 0.85 | SMN1; SMN2 (0.53) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL2619317 | 0.83 | MAPK14 (0.47) | HIF1AKCNH2WNT3AKMT2AHPGDS | |
| SCHEMBL12214394 | 0.83 | SMN1; SMN2 (0.50) | KMT2ARAB9AMEN1SMN1; SMN2MTOR | |
| SCHEMBL2620358 | 0.80 | F10 (0.47) | KMT2AMEN1MTORSCN9A | |
| SCHEMBL26033258 | 0.80 | CSF1R (0.54) | FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888364-B2 | Pyridyl inhibitors of hedgehog signalling | CURIS, INC. (US) | 2011-02-15 | — | — | US | disclosed |