Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.58 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12009346 | 1.00 | ADORA2A (0.60) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL12009350 | 0.99 | ADORA2A (0.58) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL12927107 | 0.99 | ADORA2A (0.58) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL12009344 | 0.97 | ADORA2A (0.59) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL12927108 | 0.97 | ADORA2A (0.59) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL13473666 | 0.94 | ADORA2A (0.59) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL13472257 | 0.93 | ADORA2A (0.56) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL12009367 | 0.93 | ADORA2A (0.56) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL12952374 | 0.93 | ADORA2A (0.61) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 | |
| SCHEMBL12952072 | 0.93 | ADORA2A (0.61) | ADORA2AADORA3ADORA1ADORA2BHSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293720-B2 | Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists | DOGWOOD PHARMACEUTICALS, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110003765-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | ADENOSINE THERAPEUTICS, LLC | 2011-01-06 | — | — | US | disclosed |
| US-20090162292-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | PGXHEALTH, LLC (US) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003765-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA3 2/4885ADORA1 3/4885 |
| US-20090162292-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA3 2/4885ADORA1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.