Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 5/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | NT5E | P21589 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709942 | 1.00 | AHCY (0.58) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL12636459 | 1.00 | AHCY (0.58) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL12960582 | 1.00 | AHCY (0.58) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL3746390 | 1.00 | AHCY (0.58) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL3750374 | 1.00 | AHCY (0.58) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL8709225 | 1.00 | AHCY (0.58) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL3746380 | 1.00 | AHCY (0.58) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL8215983 | 0.89 | AHCY (0.55) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL8222030 | 0.89 | AHCY (0.55) | AHCYADORA2AADORA3ADORA1NT5E | |
| SCHEMBL8215986 | 0.89 | AHCY (0.55) | AHCYADORA2AADORA3ADORA1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875733-B2 | Nucleosides; RNA interference; gene expression inhibition; for use in therapeutic, diagnostic, and research applications involving gene silencing | ISIS PHARMACEUTICALS, INC. (US) | 2011-01-25 | — | — | US | disclosed |