AHCY

Adenosylhomocysteinase · P23526 · AHCY on Sugi Atlas →

20,121 patent compounds predicted against AHCY, 11,761 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1197677	0.58	20/20
SCHEMBL1024485	0.53	20/20
SCHEMBL1027422	0.54	19/20
Hydrochloric Acid (SCHEMBL1197460)	0.53	19/20
Hydrochloric Acid (SCHEMBL1197879)	0.51	19/20
Hydrochloric Acid (SCHEMBL1025708)	0.55	18/20
Hydrochloric Acid (SCHEMBL1028244)	0.51	18/20
SCHEMBL863521	1.00	17/20
Aristeromycin (SCHEMBL692209)	1.00	16/20
Noraristeromycin (SCHEMBL1231088)	1.00	16/20
SCHEMBL863387	0.82	16/20
SCHEMBL859911	0.66	16/20
SCHEMBL1197505	0.51	16/20
SCHEMBL536023	0.79	15/20
SCHEMBL864735	0.60	15/20
SCHEMBL1026487	0.53	15/20
SCHEMBL1197730	0.50	15/20
SCHEMBL600033	0.73	14/20
SCHEMBL600034	0.73	14/20
SCHEMBL863696	0.69	14/20

Clinical trials — most relevant to AHCY by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine	PHASE2/PHASE3	UNKNOWN
Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine	PHASE1/PHASE2	COMPLETED
Folate Rechallenge	PHASE2	COMPLETED
Betaine METABOLISM OF PATIENTS With Homocystinuria	PHASE2	COMPLETED
Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine	PHASE1	COMPLETED
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL	EARLY_PHASE1	UNKNOWN
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels	nan	COMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Proof of Concept Creatine Supplementation for Homocystinuria Study	nan	ACTIVE_NOT_RECRUITING
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Harmonized Micronutrient Project	nan	COMPLETED
Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA)	nan	RECRUITING
Treating Oxidative Stress and the Metabolic Pathology of Autism	nan	COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
The Role of Transthoracic Echocardiography in Diagnosis of Pulmonary Hypertension of Infants With Bronchopulmonary Dysplasia	nan	COMPLETED
Homocysteine and Coronary Artery Disease	nan	COMPLETED
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients	nan	COMPLETED
The Effect of Dietary Management and Cysteine Supplementation on Growth Parameters and Biochemical Control for Pediatric Qatari Patients Affected with Classical B6 Non-responsive Homocystinuria.	nan	NOT_YET_RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease	nan	UNKNOWN
Early Nutritional Intervention in Patients With Autism Spectrum Disorders	nan	COMPLETED
Effects of Exercise on Metabolic Parameters in Classical Homocystinuria	nan	COMPLETED
Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Pakistan	nan	WITHDRAWN
Study of Homocysteine Metabolism in Homocystinuria	nan	COMPLETED
The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions	nan	COMPLETED
Vitamin B-6 and Glutathione on Inflammation, Homocysteine, Oxidative Stress and Antioxidant Capacities	nan	UNKNOWN
Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma	nan	UNKNOWN
Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma	nan	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Egg Intake, Metabolic Outcomes and Choline Levels	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a AHCY binder may also engage these)

Protein	Name	Similarity
Q4R596	—	1.000	Q4R596 →
P10760	—	1.000	P10760 →
P50247	—	1.000	P50247 →
P51893	—	1.000	P51893 →
Q3MHL4	—	1.000	Q3MHL4 →
A1VFZ7	—	1.000	A1VFZ7 →
Q3AQC2	—	1.000	Q3AQC2 →
Q710C4	—	1.000	Q710C4 →
Q8A407	—	1.000	Q8A407 →
A6GW32	—	1.000	A6GW32 →
O93477	—	1.000	O93477 →
B3QMF5	—	1.000	B3QMF5 →
Q72EH1	—	1.000	Q72EH1 →
B7V419	—	1.000	B7V419 →
Q8KEG8	—	1.000	Q8KEG8 →
O76757	—	1.000	O76757 →
B6J3R0	—	1.000	B6J3R0 →
Q83A77	—	1.000	Q83A77 →
P10819	—	1.000	P10819 →
Q01VU1	—	0.999	Q01VU1 →
Q9I685	—	0.999	Q9I685 →
Q11CD0	—	0.999	Q11CD0 →
Q04NN6	—	0.999	Q04NN6 →
B6J6H1	—	0.998	B6J6H1 →
B0KM00	—	0.998	B0KM00 →
Q60CG8	—	0.998	Q60CG8 →
Q3B532	—	0.998	Q3B532 →
Q6N2N5	—	0.998	Q6N2N5 →
A1WXM7	—	0.998	A1WXM7 →
B8DR41	—	0.998	B8DR41 →