Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | RORA | P35398 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | RORB | Q92753 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30485670 | 0.87 | PGR (0.68) | PGRMAPK8ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6362477 | 0.87 | PGR (0.68) | PGRMAPK8ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL12933336 | 0.81 | TOP2A (0.51) | PGRALDH1A1KDM4ECNR2HDAC1 | |
| SCHEMBL12963428 | 0.81 | PGR (0.61) | PGRMAPK8ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL12933344 | 0.81 | PARG (0.43) | PGRALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL12933334 | 0.77 | GAA (0.52) | ALDH1A1SMN1; SMN2KMT2ACNR2HDAC1 | |
| SCHEMBL12933342 | 0.77 | P2RX4 (0.62) | SMN1; SMN2KMT2ATP53MAPK1HDAC1 | |
| SCHEMBL6366020 | 0.77 | PGR (0.64) | PGRMAPK8ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL16092741 | 0.76 | PGR (0.55) | PGRMAPK8ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13111957 | 0.75 | CYP1A2 (0.56) | ALDH1A1KDM4EKMT2AHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |