Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 19/20 | 0.79 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.79 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.79 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12935993 | 0.90 | ADORA3 (0.80) | ADORA3ADORA1ADORA2BADORA2A | |
| SCHEMBL12935990 | 0.85 | ADORA3 (0.74) | ADORA3ADORA1ADORA2BADORA2AADRA2A | |
| SCHEMBL14408092 | 0.83 | ADORA3 (0.70) | ADORA3ADORA1ADORA2BADORA2A | |
| SCHEMBL19843955 | 0.83 | ADORA3 (0.70) | ADORA3ADORA1ADORA2BADORA2A | |
| SCHEMBL29762306 | 0.83 | ADORA3 (0.89) | ADORA3ADORA1ADORA2BADORA2A | |
| SCHEMBL8921421 | 0.81 | ADORA3 (0.84) | ADORA3ADORA1ADORA2BADORA2A | |
| SCHEMBL29073477 | 0.80 | ADORA3 (0.65) | ADORA3ADORA1ADORA2BADORA2AADRA2A | |
| SCHEMBL29762311 | 0.80 | ADORA3 (0.65) | ADORA3ADORA1ADORA2BADORA2AADRA2A | |
| SCHEMBL29073483 | 0.80 | ADORA3 (0.65) | ADORA3ADORA1ADORA2BADORA2AADRA2A | |
| SCHEMBL26628399 | 0.80 | ADORA3 (0.65) | ADORA3ADORA1ADORA2BADORA2AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863253-B2 | Purine Derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2011-01-04 | — | — | US | disclosed |