Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935949 | 0.93 | PIK3CA (0.40) | PIK3CAMTORHSP90AA1HSP90AB1PIK3C3 | |
| SCHEMBL13105844 | 0.86 | PIK3CA (0.32) | PIK3CAMTOR | |
| SCHEMBL12947582 | 0.85 | NPC1 (0.34) | PIK3CAMTORMAPK14PIK3C3 | |
| SCHEMBL12947583 | 0.84 | PIK3CA (0.40) | PIK3CAMTORPIK3C3 | |
| SCHEMBL13105449 | 0.84 | MAPK14 (0.35) | MAPK14PIK3C3 | |
| SCHEMBL12947718 | 0.84 | DYRK1A (0.32) | PIK3CAMTOR | |
| SCHEMBL12947604 | 0.83 | NPC1 (0.37) | PIK3CAMTOR | |
| SCHEMBL12947753 | 0.82 | PIK3CA (0.38) | PIK3CAMTORPIK3C3 | |
| SCHEMBL954626 | 0.81 | PIK3CA (0.42) | PIK3CAMTOR | |
| SCHEMBL952919 | 0.79 | PIK3C3 (0.40) | PIK3CAMTORMAPK14PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003806-A1 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003806-A1 | Heteroaryls and uses thereof | RICTOR, MTOR, AKT1S1 | PIK3CA 9/4885MTOR 2/4885MAPK14 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.