Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947751 | 0.93 | PIK3CA (0.33) | PIK3CAMTORPIK3C3HSP90AA1HSP90AB1 | |
| SCHEMBL13105844 | 0.92 | PIK3CA (0.32) | PIK3CAMTORSCN9A | |
| SCHEMBL12947583 | 0.92 | PIK3CA (0.40) | PIK3CAMTORHPGDMEN1LMNA | |
| SCHEMBL954626 | 0.89 | PIK3CA (0.42) | PIK3CAMTORHPGDMEN1LMNA | |
| SCHEMBL12947753 | 0.89 | PIK3CA (0.38) | PIK3CAMTORMEN1LMNAGAA | |
| SCHEMBL952919 | 0.87 | PIK3C3 (0.40) | PIK3CAMTORGSK3AGSK3BPIK3C3 | |
| SCHEMBL12918036 | 0.86 | PIK3C3 (0.31) | PIK3CAMTORPIK3C3 | |
| SCHEMBL12918088 | 0.85 | PIK3CA (0.39) | PIK3CAMTORMEN1KMT2AGSK3A | |
| SCHEMBL15935947 | 0.85 | PIK3CA (0.39) | PIK3CAMTORHPGDMEN1LMNA | |
| SCHEMBL12947642 | 0.85 | PIK3CA (0.40) | PIK3CAMTORHPGDMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139589-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-8796314-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |