Mofegiline

Mofegiline

SCHEMBL1295043

NCC(=CF)CCc1ccc(F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 1.00
AOC2 O75106 5/20 1.00
MAOA P21397 5/20 1.00
AOC3 Q16853 2/20 1.00
DAO P14920 2/20 0.57
TAAR1 Q96RJ0 3/20 0.50
LOXL2 Q9Y4K0 1/20 0.43
FFAR1 O14842 1/20 0.41
SLC5A1 P13866 1/20 0.39
SLC5A2 P31639 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mofegiline SCHEMBL147813 1.00 MAOB (1.00) MAOBAOC2MAOAAOC3DAO
Mofegiline SCHEMBL1295041 1.00 MAOB (1.00) MAOBAOC2MAOAAOC3DAO
Mofegiline SCHEMBL14005358 1.00 MAOB (1.00) MAOBAOC2MAOAAOC3DAO
Mofegiline SCHEMBL343685 0.98 MAOB (0.96) MAOBAOC2MAOAAOC3DAO
Mofegiline SCHEMBL125286 0.98 MAOB (0.96) MAOBAOC2MAOAAOC3DAO
Mofegiline SCHEMBL343686 0.98 MAOB (0.96) MAOBAOC2MAOAAOC3DAO
SCHEMBL1295016 0.84 MAOB (0.72) MAOBAOC2MAOAAOC3DAO
SCHEMBL1295522 0.84 MAOB (0.72) MAOBAOC2MAOAAOC3DAO
SCHEMBL1294767 0.84 MAOB (0.72) MAOBAOC2MAOAAOC3DAO
SCHEMBL1295015 0.84 MAOB (0.72) MAOBAOC2MAOAAOC3DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0875499-A2 Process for the crystallisation of alkali metal salts of diformylamide HOECHST MARION ROUSSEL, INC. (US) 1998-11-04 EP claimed
US-5679854-A Process for the preparation of (epsilon)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane and novel intermediate thereof HOECHST MARION ROUSSEL, INC. (US) 1997-10-21 US claimed
EP-0642338-B1 USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE MERRELL PHARMA INC (US) 1997-01-22 EP claimed
EP-0720475-A1 TRANSDERMAL DEVICE CONTAINING (E)-2-(P-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE MERRELL PHARMACEUTICALS INC. (US) 1996-07-10 EP claimed
WO-1995008325-A1 TRANSDERMAL DEVICE CONTAINING (E)-2-(P-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE MERRELL PHARMACEUTICALS INC. (US) 1995-03-30 WO claimed
EP-0642338-A1 USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE. MERRELL DOW PHARMA (US) 1995-03-15 EP claimed
WO-1993024120-A1 USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE MERRELL DOW PHARMACEUTICALS INC. (US) 1993-12-09 WO claimed
EP-0295604-A1 (E)-2-(p-Fluorophenethyl)-3-fluoroallylamine MERRELL DOW PHARMACEUTICALS INC. (US) 1988-12-21 EP claimed
US-10576148-B2 Use of VAP-1 inhibitors for treating fibrotic conditions BIOTIE THERAPIES CORP. (FI) 2020-03-03 US disclosed
US-20180071388-A1 USE OF VAP-1 INHIBITORS FOR TREATING FIBROTIC CONDITIONS BIOTIE THERAPIES CORP. (FI) 2018-03-15 US disclosed
EP-2475387-B1 VAP-1 INHIBITORS FOR USE IN TREATING FIBROTIC CONDITIONS BIOTIE THERAPIES CORP (FI) 2017-11-01 EP disclosed
US-9795671-B2 Use of VAP-1 inhibitors for treating fibrotic conditions BIOTIE THERAPIES CORP. (FI) 2017-10-24 US disclosed
US-20130195883-A1 USE OF VAP-1 INHIBITORS FOR TREATING FIBROTIC CONDITIONS THE UNIVERSITY OF BIRMINGHAM (GB) 2013-08-01 US disclosed
EP-2475387-A1 USE OF VAP-1 INHIBITORS FOR TREATING FIBROTIC CONDITIONS Biotie Therapies Corp. (FI) 2012-07-18 EP disclosed
WO-1993024120-A1 USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE MERRELL DOW PHARMACEUTICALS INC. (US) 1993-12-09 WO disclosed
WO-1993024120-A1 USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE MERRELL DOW PHARMACEUTICALS INC. (US) 1993-12-09 WO disclosed
WO-1993023023-A1 METHOD FOR PREVENTING ENDOTHELIUM DAMAGE IN MAMMALS AND FOR ALLEVIATING PAIN ASSOCIATED WITH GOUT AND ARTHRITIS UNIVERSITY OF SASKATCHEWAN (CA) 1993-11-25 WO disclosed
EP-0330218-A2 Inhibitors of lysyl oxidase MERRELL DOW PHARMACEUTICALS INC. (US) 1989-08-30 EP disclosed
EP-0295604-A1 (E)-2-(p-Fluorophenethyl)-3-fluoroallylamine MERRELL DOW PHARMACEUTICALS INC. (US) 1988-12-21 EP disclosed
EP-0295604-A1 (E)-2-(p-Fluorophenethyl)-3-fluoroallylamine MERRELL DOW PHARMACEUTICALS INC. (US) 1988-12-21 EP disclosed