Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.39 |
| ▸ | CDK9 | P50750 | 6/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 5/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930883 | 0.91 | CDK2 (0.43) | CDK2CDK9CDK5CDK1GAA | |
| SCHEMBL14043244 | 0.86 | CDK2 (0.40) | CDK2CDK9CDK5CDK1GAA | |
| SCHEMBL12954403 | 0.85 | CDK2 (0.43) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL14516595 | 0.82 | GSK3B (0.39) | CDK2CDK9CDK5CDK1GAA | |
| SCHEMBL11930874 | 0.81 | GSK3B (0.42) | CDK2GAAPOLBKMT2AMEN1 | |
| SCHEMBL14545927 | 0.78 | GSK3B (0.43) | CDK2GAAPOLBKMT2AMEN1 | |
| SCHEMBL12953588 | 0.78 | NPC1 (0.48) | CDK2GAAPOLBKMT2AMEN1 | |
| SCHEMBL14194674 | 0.77 | KDM4E (0.38) | CDK2CDK9CDK5CDK1GAA | |
| SCHEMBL12953797 | 0.75 | CDK2 (0.49) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL12953697 | 0.75 | CDK2 (0.47) | CDK2CDK9CDK5CDK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |