Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930874 | 0.90 | GSK3B (0.42) | GSK3BCDK2CDK7POLBGAA | |
| SCHEMBL14516595 | 0.86 | GSK3B (0.39) | GSK3BCDK2CDK7POLBGAA | |
| SCHEMBL11930883 | 0.79 | CDK2 (0.43) | GSK3BCDK2CDK7POLBGAA | |
| SCHEMBL11930865 | 0.79 | GSK3B (0.65) | GSK3BCDK2 | |
| SCHEMBL11930866 | 0.78 | GSK3B (0.63) | GSK3BCDK2CDK7CCNE1CCNH | |
| SCHEMBL12953004 | 0.78 | CDK2 (0.39) | GSK3BCDK2CDK7POLBGAA | |
| SCHEMBL11930875 | 0.77 | CDK2 (0.64) | GSK3BCDK2CCNE1 | |
| SCHEMBL14043226 | 0.77 | CDK2 (0.54) | GSK3BCDK2CDK7CCNE1CCNH | |
| SCHEMBL12954030 | 0.77 | CDK2 (0.54) | GSK3BCDK2CDK7CCNE1CCNH | |
| SCHEMBL14043244 | 0.75 | CDK2 (0.40) | GSK3BCDK2CDK7POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |