Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018730 | 0.88 | HRH3 (0.40) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL1018075 | 0.87 | HRH3 (0.49) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL1016623 | 0.86 | PRMT5 (0.39) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL1019051 | 0.85 | HRH3 (0.47) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL1016412 | 0.84 | HRH3 (0.46) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL1014200 | 0.83 | PKM (0.44) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL1604044 | 0.83 | PKM (0.44) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL12730550 | 0.81 | PRMT5 (0.39) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL1017462 | 0.81 | HRH3 (0.51) | PRMT5WDR77HRH3MAPK1ALDH1A1 | |
| SCHEMBL1018368 | 0.81 | PRMT5 (0.41) | PRMT5WDR77HRH3MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1998620-B1 | PIPERAZINYL OXOALKYL TETRAHYDROISOQUINOLINES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2011-01-12 | — | — | EP | disclosed |