Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.58 |
| ▸ | CDK2 | P24941 | 12/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953547 | 0.92 | GSK3B (0.59) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL13305345 | 0.84 | GSK3B (0.59) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL12953741 | 0.81 | GSK3B (0.41) | GSK3BCDK2CCNE1 | |
| SCHEMBL13305343 | 0.81 | GSK3B (0.45) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL12953804 | 0.77 | GSK3B (0.69) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL12953020 | 0.77 | GSK3B (0.71) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL12954193 | 0.77 | GSK3B (0.68) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL12953205 | 0.76 | GSK3B (0.70) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL12953159 | 0.75 | GSK3B (0.78) | GSK3BCDK2CCNE1 | |
| SCHEMBL14545204 | 0.75 | GSK3B (0.74) | GSK3BCDK2CCNE1CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |