Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
| ▸ | STK16 | O75716 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13118708 | 0.83 | GSK3B (0.46) | GSK3BKMT2AUSP2HPGDCASP7 | |
| SCHEMBL12953740 | 0.82 | GSK3B (0.64) | GSK3BCCNE1CDK2 | |
| SCHEMBL12953547 | 0.81 | GSK3B (0.59) | GSK3BCCNE1CDK2 | |
| SCHEMBL12953833 | 0.81 | GSK3B (0.58) | GSK3BCCNE1CDK2 | |
| SCHEMBL13118710 | 0.81 | GSK3B (0.44) | GSK3BKMT2AUSP2HPGDCASP7 | |
| SCHEMBL13121485 | 0.75 | GSK3B (0.66) | GSK3BCCNE1CDK2 | |
| SCHEMBL12953742 | 0.75 | GSK3B (0.61) | GSK3BCCNE1CDK2 | |
| SCHEMBL13305202 | 0.75 | GSK3B (0.52) | GSK3BKMT2AUSP2HPGDCASP7 | |
| SCHEMBL14561101 | 0.73 | GSK3B (0.66) | GSK3BCCNE1CDK2 | |
| SCHEMBL13121502 | 0.72 | GSK3B (0.67) | GSK3BCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |