Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.52 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289819 | 0.86 | GSK3B (0.52) | GSK3BCDK2CCNE1 | |
| SCHEMBL13122798 | 0.86 | GSK3B (0.68) | GSK3BCDK2CCNE1 | |
| SCHEMBL13304782 | 0.79 | GSK3B (0.72) | GSK3BCDK2CCNE1KDM4EMEN1 | |
| SCHEMBL13305679 | 0.78 | GSK3B (0.74) | GSK3BCDK2CCNE1 | |
| SCHEMBL13305242 | 0.77 | GSK3B (0.56) | GSK3BCDK2CCNE1 | |
| SCHEMBL12952910 | 0.77 | GSK3B (0.76) | GSK3BCDK2CCNE1 | |
| SCHEMBL1368617 | 0.76 | CDK7 (0.68) | CDK2CCNE1 | |
| SCHEMBL24670112 | 0.76 | GSK3B (0.57) | GSK3BCDK2CCNE1 | |
| SCHEMBL12954230 | 0.75 | GSK3B (0.73) | GSK3BCDK2CCNE1 | |
| SCHEMBL12953651 | 0.74 | GSK3B (0.71) | GSK3BCDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |