Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.59 |
| ▸ | CDK2 | P24941 | 9/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953632 | 0.97 | GSK3B (0.58) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL12953300 | 0.95 | GSK3B (0.61) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL14043159 | 0.88 | GSK3B (0.67) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL13117972 | 0.86 | GSK3B (0.61) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL14562350 | 0.85 | GSK3B (0.63) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL12953533 | 0.85 | GSK3B (0.65) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953622 | 0.85 | GSK3B (0.65) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13122691 | 0.84 | GSK3B (0.64) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL13122637 | 0.84 | GSK3B (0.67) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL13122482 | 0.84 | GSK3B (0.59) | GSK3BCDK2CCNA2CCNA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |