Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14545872 | 0.92 | GSK3B (0.53) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13118923 | 0.91 | GSK3B (0.69) | GSK3BCCNE1CDK2 | |
| SCHEMBL14545867 | 0.87 | GSK3B (0.59) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13304983 | 0.86 | GSK3B (0.61) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL14545239 | 0.83 | GSK3B (0.55) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL14418925 | 0.83 | GSK3B (0.53) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13119192 | 0.83 | GSK3B (0.65) | GSK3BCCNE1CDK2 | |
| SCHEMBL13288832 | 0.83 | GSK3B (0.58) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13118844 | 0.83 | GSK3B (0.73) | GSK3BCCNE1CDK2 | |
| SCHEMBL14418926 | 0.82 | GSK3B (0.59) | GSK3BCHEK1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |