Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120500 | 0.91 | GSK3B (0.71) | GSK3BTSHRMAPTCDK2CCNE1 | |
| SCHEMBL14613487 | 0.91 | GSK3B (0.56) | GSK3BTSHRMAPTPKMCHEK1 | |
| SCHEMBL14613279 | 0.89 | GSK3B (0.54) | GSK3BTSHRMAPTCHEK1CDK2 | |
| SCHEMBL13289097 | 0.88 | GSK3B (0.59) | GSK3BTSHRMAPTPKMCHEK1 | |
| SCHEMBL12954475 | 0.87 | GSK3B (0.58) | GSK3BTSHRCHEK1 | |
| SCHEMBL13289362 | 0.87 | GSK3B (0.61) | GSK3BTSHRCHEK1CDK2ALDH1A1 | |
| SCHEMBL13305374 | 0.87 | GSK3B (0.61) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13289405 | 0.87 | GSK3B (0.57) | GSK3BTSHRCHEK1CDK2CCNE1 | |
| SCHEMBL13289388 | 0.86 | GSK3B (0.56) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13289104 | 0.86 | GSK3B (0.56) | GSK3BCHEK1CDK2KMT2ACCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |