Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.59 |
| ▸ | IL1B | P01584 | 17/20 | 0.59 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019186 | 0.90 | P2RX7 (0.61) | P2RX7IL1B | |
| SCHEMBL1018175 | 0.82 | P2RX7 (0.68) | P2RX7IL1B | |
| SCHEMBL1020307 | 0.80 | P2RX7 (0.66) | P2RX7IL1B | |
| SCHEMBL1020535 | 0.78 | P2RX7 (0.52) | P2RX7IL1B | |
| SCHEMBL1020208 | 0.77 | P2RX7 (0.81) | P2RX7IL1B | |
| SCHEMBL12955285 | 0.76 | P2RX7 (0.64) | P2RX7IL1B | |
| SCHEMBL1020145 | 0.76 | P2RX7 (0.51) | P2RX7IL1B | |
| SCHEMBL1020294 | 0.76 | P2RX7 (0.51) | P2RX7IL1B | |
| SCHEMBL1020902 | 0.75 | P2RX7 (0.53) | P2RX7IL1B | |
| SCHEMBL1019257 | 0.75 | P2RX7 (0.53) | P2RX7IL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105164-B1 | Novel P2X7R antagonists and their use | AFFECTIS PHARMACEUTICALS AG (DE) | 2011-01-12 | — | — | EP | disclosed |