Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.70 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21148321 | 1.00 | GAA (1.00) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL13301309 | 1.00 | GAA (1.00) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL16444993 | 1.00 | GAA (1.00) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL12717587 | 1.00 | GAA (1.00) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL12717590 | 1.00 | GAA (1.00) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL18457700 | 1.00 | GAA (1.00) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL12960964 | 1.00 | GAA (1.00) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL14371364 | 1.00 | GAA (1.00) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL29851816 | 0.88 | GAA (0.79) | GAAOPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL14371362 | 0.88 | GAA (0.79) | GAAOPRM1OPRD1OPRK1MRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11142502-B2 | (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof | MALLINCKRODT LLC (US) | 2021-10-12 | — | — | US | disclosed |
| US-20200172488-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC | 2020-06-04 | — | — | US | disclosed |
| US-9562014-B2 | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof | MALLINCKRODT LLC (US) | 2017-02-07 | — | — | US | disclosed |
| US-20170029432-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT ENTERPRISES LLC | 2017-02-02 | — | — | US | disclosed |
| US-20110015219-A1 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof | MALLINCKRODT INC. (US) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029432-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | TLR9, TLR3, TLR7 | GAA 1100/4885OPRM1 5/4885OPRD1 13/4885 |
| US-11142502-B2 | (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof | TLR9, TLR3, TLR7 | GAA 1100/4885OPRM1 5/4885OPRD1 13/4885 |
| US-20200172488-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | TLR9, TLR3, TLR7 | GAA 1100/4885OPRM1 5/4885OPRD1 13/4885 |
| US-20110015219-A1 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof | TLR9, TLR3, TLR1 | GAA 2289/4885OPRM1 17/4885OPRD1 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.