Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22288213 | 0.93 | KMT2A (0.61) | KMT2AATMTLR9KDM4EMAPT | |
| SCHEMBL22288240 | 0.93 | KMT2A (0.61) | KMT2AATMTLR9KDM4EMAPT | |
| SCHEMBL31087686 | 0.93 | KMT2A (0.61) | KMT2AATMTLR9KDM4EMAPT | |
| SCHEMBL12964188 | 0.87 | KMT2A (0.54) | KMT2AATMTLR9KDM4EMAPT | |
| SCHEMBL12964189 | 0.87 | KMT2A (0.73) | KMT2AATMTLR9KDM4EMAPT | |
| SCHEMBL12964181 | 0.87 | KMT2A (0.54) | KMT2AATMTLR9KDM4EMAPT | |
| SCHEMBL1550580 | 0.87 | KMT2A (0.77) | KMT2AATMTLR9KDM4EMAPT | |
| SCHEMBL12964204 | 0.87 | KMT2A (0.77) | KMT2AATMTLR9KDM4EMAPT | |
| SCHEMBL18082983 | 0.86 | KDM4E (0.65) | KDM4EMAPTALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL18082972 | 0.85 | KMT2A (0.81) | KMT2AATMTLR9KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2691377-B1 | AMINOQUINOXALINE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENT (C N R S ) (FR) | 2018-03-07 | — | — | EP | disclosed |
| EP-2691377-B1 | AMINOQUINOXALINE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENT (C N R S ) (FR) | 2018-03-07 | — | — | EP | disclosed |
| US-9434701-B2 | Aminoquinoxaline derivatives for treatment of neurodegenerative diseases | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2016-09-06 | — | — | US | disclosed |
| US-9434701-B2 | Aminoquinoxaline derivatives for treatment of neurodegenerative diseases | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2016-09-06 | — | — | US | disclosed |
| WO-2012131080-A1 | AMINOQUINOXALINE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-10-04 | — | — | WO | disclosed |