Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22112750 | 0.90 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL1499521 | 0.86 | HDAC6 (0.50) | KMT2AMEN1SMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL1499516 | 0.86 | HDAC6 (0.50) | KMT2AMEN1SMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL29973275 | 0.83 | SMN1; SMN2 (0.51) | KMT2AMEN1SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL1499583 | 0.83 | SMN1; SMN2 (0.51) | KMT2AMEN1SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL1499581 | 0.83 | SMN1; SMN2 (0.51) | KMT2AMEN1SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL1499328 | 0.78 | IGF1R (0.44) | KMT2AMEN1HDAC6HDAC3HDAC1 | |
| SCHEMBL1499529 | 0.78 | IGF1R (0.44) | KMT2AMEN1SMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL1499327 | 0.78 | IGF1R (0.44) | KMT2AMEN1HDAC6HDAC3HDAC1 | |
| SCHEMBL1499526 | 0.78 | IGF1R (0.44) | KMT2AMEN1SMN1; SMN2HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131656-A2 | COMPOUNDS FOR USE AS THERAPEUTIC AGENTS AFFECTING P53 EXPRESSION AND/OR ACTIVITY | SOCIÉTÉ SPLICOS (FR) | 2012-10-04 | — | — | WO | disclosed |