Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 7/20 | 0.51 |
| ▸ | CDC7 | O00311 | 7/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | MARK3 | P27448 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899938 | 0.84 | LIMK1 (0.66) | LIMK1CDC7DBF4CLK1MAPT | |
| SCHEMBL12969721 | 0.81 | LIMK1 (0.65) | LIMK1CDC7DBF4CLK1GRM4 | |
| SCHEMBL4900157 | 0.78 | HPGD (0.62) | LIMK1CDC7DBF4CLK1MAPT | |
| SCHEMBL4899880 | 0.78 | KDM4E (0.62) | LIMK1CDC7DBF4CLK1MAPT | |
| SCHEMBL4905558 | 0.78 | CDC7 (0.66) | LIMK1CDC7DBF4CLK1MAPT | |
| SCHEMBL4894356 | 0.78 | HPGD (0.58) | LIMK1CLK1MAPT | |
| SCHEMBL4899003 | 0.77 | MEN1 (0.59) | LIMK1CDC7DBF4CLK1MAPT | |
| SCHEMBL4902783 | 0.76 | PPARG (0.64) | LIMK1CDC7DBF4CLK1PLK4 | |
| SCHEMBL259291 | 0.73 | CDC7 (0.66) | LIMK1CDC7DBF4CLK1MAPT | |
| SCHEMBL4899997 | 0.71 | MAPT (0.50) | LIMK1MAPTMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131297-A1 | PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE | BAELL JONATHAN BAYLDON (AU) | 2012-10-04 | — | — | WO | disclosed |