Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 3/20 | 0.48 |
| ▸ | CDC7 | O00311 | 3/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899938 | 0.93 | LIMK1 (0.66) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4899880 | 0.89 | KDM4E (0.62) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4902783 | 0.86 | PPARG (0.64) | HPGDPTK2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL259291 | 0.81 | CDC7 (0.66) | HPGDLIMK1KDM4EMAPTPPARG | |
| SCHEMBL4905558 | 0.81 | CDC7 (0.66) | HPGDLIMK1KDM4EMAPTCLK1 | |
| SCHEMBL4894356 | 0.81 | HPGD (0.58) | HPGDLIMK1KDM4EMAPTNPSR1 | |
| SCHEMBL4903351 | 0.81 | CDC7 (0.64) | HPGDLIMK1MAPTCLK1CDC7 | |
| SCHEMBL4899003 | 0.80 | MEN1 (0.59) | LIMK1KDM4EMAPTCLK1CDC7 | |
| SCHEMBL4899997 | 0.79 | MAPT (0.50) | HPGDLIMK1KDM4EMAPTNPSR1 | |
| SCHEMBL12969725 | 0.78 | LIMK1 (0.51) | LIMK1MAPTCLK1CDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131297-A1 | PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE | BAELL JONATHAN BAYLDON (AU) | 2012-10-04 | — | — | WO | disclosed |
| US-20080008720-A1 | Substituted Tricyclic Heterocycles and their Uses | CYWIN CHARLES L | 2008-01-10 | — | — | US | disclosed |
| US-7291733-B2 | Substituted tricyclic heterocycles and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1673374-A2 | SUBSTITUTED TRICYCLIC HETEROCYCLES AND THEIR USES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-06-28 | — | — | EP | disclosed |
| US-20050101601-A1 | Substituted tricyclic heterocycles and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | US | disclosed |
| WO-2005035537-A2 | SUBSTITUTED TRICYCLIC HETEROCYCLES AND THEIR USES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101601-A1 | Substituted tricyclic heterocycles and their uses | LTC4S, NQO1, CBR3 | HPGD 53/4885PTK2B 3409/4885CYP1A2 67/4885 |
| US-20080008720-A1 | Substituted Tricyclic Heterocycles and their Uses | LTC4S, NQO1, CBR3 | HPGD 53/4885PTK2B 3409/4885CYP1A2 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.