SCHEMBL1298069

SCHEMBL1298069

Brc1ccc2c(c1)c1ccc3c4cc(Br)ccc4n(-c4ccccc4)c3c1n2-c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 4/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ ATM Q13315 1/20 0.44
▸ RXFP1 Q9HBX9 3/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ DNM1 Q05193 1/20 0.38
▸ LIG1 P18858 1/20 0.38
▸ CA9 Q16790 2/20 0.37
▸ DNMT1 P26358 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ TSPO P30536 2/20 0.36
▸ GABRA1 P14867 1/20 0.35
▸ GABRG2 P18507 1/20 0.35
▸ GABRB3 P28472 1/20 0.35
▸ GABRA5 P31644 1/20 0.35
▸ GABRA3 P34903 1/20 0.35
▸ GABRA2 P47869 1/20 0.35
▸ GABRA6 Q16445 1/20 0.35
▸ CA12 O43570 1/20 0.35
▸ MEN1 O00255 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8819301 0.95 L3MBTL1 (0.53) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL16170195 0.93 L3MBTL1 (0.47) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL16162742 0.90 L3MBTL1 (0.41) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL181466 0.89 L3MBTL1 (0.56) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL29362953 0.89 L3MBTL1 (0.56) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL16162967 0.88 L3MBTL1 (0.52) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL12126569 0.88 L3MBTL1 (0.41) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL20427209 0.87 L3MBTL1 (0.43) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL15594704 0.86 L3MBTL1 (0.35) L3MBTL1KDM4EATMRXFP1ALDH1A1
SCHEMBL38661092 0.86 L3MBTL1 (0.53) L3MBTL1KDM4EATMRXFP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8637857-B2 Substituted carbazole derivatives and use thereof in organic electronics BASF SE (DE) 2014-01-28 — — US disclosed
US-8637857-B2 Substituted carbazole derivatives and use thereof in organic electronics BASF SE (DE) 2014-01-28 — — US disclosed
US-8637857-B2 Substituted carbazole derivatives and use thereof in organic electronics BASF SE (DE) 2014-01-28 — — US disclosed
US-20110266528-A1 SUBSTITUTED CARBAZOLE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTRONICS BASF SE (DE) 2011-11-03 — — US disclosed
US-20110266528-A1 SUBSTITUTED CARBAZOLE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTRONICS BASF SE (DE) 2011-11-03 — — US disclosed
US-20110266528-A1 SUBSTITUTED CARBAZOLE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTRONICS BASF SE (DE) 2011-11-03 — — US disclosed
WO-2011125020-A1 SUBSTITUTED CARBAZOLE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTRONICS BASF SE (DE) 2011-10-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110266528-A1 SUBSTITUTED CARBAZOLE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTRONICS NR2E3, CHRNA5, CHRNA4 L3MBTL1 3318/4885KDM4E 1756/4885ATM 3574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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