Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | GABRE | P78334 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298526 | 1.00 | PPARG (0.38) | PPARGAKR1C3AKR1C2TAS2R14KDM4E | |
| SCHEMBL1298821 | 0.90 | LMNA (0.44) | PPARGAKR1C3AKR1C2LMNACSNK2A1 | |
| SCHEMBL1298823 | 0.90 | LMNA (0.44) | PPARGAKR1C3AKR1C2LMNACSNK2A1 | |
| SCHEMBL12106915 | 0.87 | TP53 (0.40) | KDM4EMAPK1LMNAGABRPGABRD | |
| SCHEMBL12103798 | 0.82 | TP53 (0.39) | TAS2R14KDM4EMAPK1LMNAGABRP | |
| SCHEMBL28124839 | 0.80 | PPARG (0.43) | PPARGAKR1C3AKR1C2TAS2R14KDM4E | |
| SCHEMBL16964208 | 0.80 | LMNA (0.45) | PPARGKDM4EMAPK1LMNACSNK2A1 | |
| SCHEMBL16964209 | 0.80 | LMNA (0.45) | PPARGKDM4EMAPK1LMNACSNK2A1 | |
| SCHEMBL1298923 | 0.71 | MEN1 (0.34) | PPARGKDM4EMAPK1LMNAMEN1 | |
| SCHEMBL1298922 | 0.71 | MEN1 (0.34) | PPARGKDM4EMAPK1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404677-B2 | Kinase inhibitors | GENOSCO (US) | 2013-03-26 | — | — | US | disclosed |
| EP-2493313-A1 | KINASE INHIBITORS | Genosco (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20110269739-A1 | KINASE INHIBITORS | OSCOTEC, INC. (KR) | 2011-11-03 | — | — | US | disclosed |
| WO-2011053861-A1 | KINASE INHIBITORS | GENOSCO (US) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269739-A1 | KINASE INHIBITORS | JAK1, LCK, MAP3K20 | PPARG 2315/4885AKR1C3 1710/4885AKR1C2 1180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.