Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 13/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854 | 0.71 | — | — | |
| SCHEMBL3141716 | 0.71 | IDO1 (0.44) | IDO1CYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL3474476 | 0.71 | AURKA (0.45) | POLB | |
| Ammonia Solution, Strong SCHEMBL27003885 | 0.69 | CYP3A4 (0.42) | IDO1CYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL20772034 | 0.69 | CYP3A4 (0.42) | IDO1CYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL10506714 | 0.69 | KDM4A (0.33) | IDO1CYP3A4CYP2D6CYP2E1CYP2A6 | |
| Hydrochloric Acid SCHEMBL11257477 | 0.69 | IDO1 (0.43) | IDO1CYP3A4CYP2D6CYP2E1CYP2A6 | |
| Hydrochloric Acid SCHEMBL30685515 | 0.68 | AURKA (0.42) | POLB | |
| Bicarbonate SCHEMBL28123369 | 0.68 | KDM4C (0.41) | IDO1CYP3A4CYP2D6CYP2E1CYP2A6 | |
| Phosphoric Acid SCHEMBL1880808 | 0.67 | IDO1 (0.37) | IDO1CYP3A4CYP2D6CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370103-A2 | PHARMACEUTICAL COMBINATIONS COMPRISING A PYRIDO[4,3-D]PYRIMIDINE DERIVED HSP90-INHIBITOR AND A HER2 INHIBITOR | Novartis AG (CH) | 2011-10-05 | — | — | EP | claimed |
| WO-2010060939-A2 | COMBINATION OF HSP90 AND HERCEPTIN INHIBITORS | NOVARTIS AG (CH) | 2010-06-03 | — | — | WO | claimed |
| EP-4516359-A3 | 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO [1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5(1H)-ONE, ANALOGS THEREOF, AND SALTS THEREOF AND METHODS FOR THEIR USE IN THERAPY | Oncoceutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| EP-4512483-A3 | 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO [1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5(1H)-ONE, ANALOGS THEREOF, AND SALTS THEREOF AND METHODS FOR THEIR USE IN THERAPY | Oncoceutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| EP-4516359-A2 | 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO [1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5(1H)-ONE, ANALOGS THEREOF, AND SALTS THEREOF AND METHODS FOR THEIR USE IN THERAPY | Oncoceutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| EP-4512483-A2 | 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO [1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5(1H)-ONE, ANALOGS THEREOF, AND SALTS THEREOF AND METHODS FOR THEIR USE IN THERAPY | Oncoceutics, Inc. (US) | 2025-02-26 | — | — | EP | disclosed |
| US-20240254123-A1 | PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS WEE1 KINASE INHIBITORS | APREA THERAPEUTICS, INC. | 2024-08-01 | — | — | US | disclosed |
| EP-4347592-A1 | PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS WEE1 KINASE INHIBITORS | Aprea Therapeutics, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| EP-3728217-B1 | CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS | HIBERCELL INC (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022256680-A1 | PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS WEE1 KINASE INHIBITORS | ATRIN PHARMACEUTICALS (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2018011570-A1 | WEE-1 INHIBITING PYRIDOPYRIMIDINONE COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2018-01-18 | — | — | WO | disclosed |
| WO-2011053861-A8 | KINASE INHIBITORS | GENOSCO (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011053861-A1 | KINASE INHIBITORS | GENOSCO (US) | 2011-05-05 | — | — | WO | disclosed |
| EP-1928875-A1 | 2-AMINO-7,8-DIHYDRO-6H-PYRIDOÝ4,3-D¨PYRIMIDIN-5-ONES | Novartis AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007041362-A1 | 2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D] PYRIMIDIN-5-ONES | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |
| US-4681881-A | 5-alkoxy-pyrido[4,3-d]pyrimidine derivatives | GODECKE AKTIENGESELLSCHAFT (DE) | 1987-07-21 | — | — | US | disclosed |
| US-4681885-A | 5-oxo-pyrido[4,3-]pyrimidine derivatives | GODECKE AKTIENGESELLSCHAFT (DE) | 1987-07-21 | — | — | US | disclosed |
| US-4681885-A | 5-oxo-pyrido[4,3-]pyrimidine derivatives | GODECKE AKTIENGESELLSCHAFT (DE) | 1987-07-21 | — | — | US | disclosed |
| EP-0189870-A1 | 5-Alkoxy-pyrido[4,3-d]pyrimidine derivatives, process for their preparation and medicaments containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1986-08-06 | — | — | EP | disclosed |
| EP-0189883-A1 | 5-Oxo-pyrido[4,3-d]pyrimidine derivatives, process for their preparation and medicaments containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1986-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240254123-A1 | PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS WEE1 KINASE INHIBITORS | WEE1, WEE2, NME1 | IDO1 3228/4885CYP3A4 2845/4885CYP2D6 2677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.